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回复104楼::
低智生物
oral tetrandrine 'could be' an effective agent for the treatment of SARS-CoV-2 infection in humans.
換再多馬甲, 智障還是智障!!
低智生物
oral tetrandrine 'could be' an effective agent for the treatment of SARS-CoV-2 infection in humans.
換再多馬甲, 智障還是智障!!
回复103楼::
小逼崽子， 天天翻墙出来喷粪累不累？
你个驴日的， 我那句话不是在实事求是。 你推崇中药， 我也不反对， 只说这个成药比较难， 存中药制剂到目前为止有多少？
啥鸡吧中药不弄成中西医结合片剂能得到广泛应用？
你要是会英语， 这文章里通篇的may/might 你看得懂吗？ 到了最后也说要做代谢动力研究和毒理研究， 离鸡吧临床远的很。
It is possible from the available evidence that oral tetrandrine could be an effective agent for the treatment of SARS-CoV-2 infection in humans.
The level of inhibition of viral replication in lung attainable with standard oral dosing of tetrandrine could be of value for the treatment, or potentially the prophylaxis (pending caveats about long-term use and toxicity) of SARS-CoV-2 infection. Prophylaxis is suggested because early administration of tetrandrine relative to infection has been shown to be more effective in vitro in the context of HCoV-OC4329 and this may also apply to SARS-CoV-2.
As tetrandrine is already licensed and used in China as an oral tablet at the doses cited above, it is probable that these doses are safe to be administered more widely. However, evidence of conclusive pharmacokinetic and toxicological studies, as well as clinical trials is required.
我不知道你是不是傻逼，不过你要是不拿无毛就在这里跟我喷粪， 你病的真不轻。
拉黑，老子路上踩了狗屎会使劲在草地上蹬几下， 但是老是看着狗屎也怪恶心的。
小逼崽子， 天天翻墙出来喷粪累不累？
你个驴日的， 我那句话不是在实事求是。 你推崇中药， 我也不反对， 只说这个成药比较难， 存中药制剂到目前为止有多少？
啥鸡吧中药不弄成中西医结合片剂能得到广泛应用？
你要是会英语， 这文章里通篇的may/might 你看得懂吗？ 到了最后也说要做代谢动力研究和毒理研究， 离鸡吧临床远的很。
It is possible from the available evidence that oral tetrandrine could be an effective agent for the treatment of SARS-CoV-2 infection in humans.
The level of inhibition of viral replication in lung attainable with standard oral dosing of tetrandrine could be of value for the treatment, or potentially the prophylaxis (pending caveats about long-term use and toxicity) of SARS-CoV-2 infection. Prophylaxis is suggested because early administration of tetrandrine relative to infection has been shown to be more effective in vitro in the context of HCoV-OC4329 and this may also apply to SARS-CoV-2.
As tetrandrine is already licensed and used in China as an oral tablet at the doses cited above, it is probable that these doses are safe to be administered more widely. However, evidence of conclusive pharmacokinetic and toxicological studies, as well as clinical trials is required.
我不知道你是不是傻逼，不过你要是不拿无毛就在这里跟我喷粪， 你病的真不轻。
拉黑，老子路上踩了狗屎会使劲在草地上蹬几下， 但是老是看着狗屎也怪恶心的。
西药是单方药剂。如果西药无法有效的话，必须求助于中医中药。
中药是复方药，主要是靠配伍，也就是多种成分的配比来实现疗效的。中医中药的研究非常难，但好中医真的是能治好疑难杂症的。
中药是复方药，主要是靠配伍，也就是多种成分的配比来实现疗效的。中医中药的研究非常难，但好中医真的是能治好疑难杂症的。
回复57楼:
低智生物
千金藤用於新冠, 英國、日本一直都都在研究!!
Potential anti-COVID-19 agents, cepharanthine and nelfinavir, and their usage for combination treatment
Hirofumi Ohashi et al. iScience. 2021.
低智生物
千金藤用於新冠, 英國、日本一直都都在研究!!
Potential anti-COVID-19 agents, cepharanthine and nelfinavir, and their usage for combination treatment
Hirofumi Ohashi et al. iScience. 2021.
回复78楼:
低智生物
英國學者：從現有證據, 口服粉防己(千金藤), 可能是治療新冠有效藥物
Pharmacological hypothesis: TPC2 antagonist tetrandrine as a potential therapeutic agent for COVID‐19
Paula M. Heister and Robin N. Poston
低智生物
英國學者：從現有證據, 口服粉防己(千金藤), 可能是治療新冠有效藥物
Pharmacological hypothesis: TPC2 antagonist tetrandrine as a potential therapeutic agent for COVID‐19
Paula M. Heister and Robin N. Poston
回复84楼:
低智生物
英國學者：從現有證據, 口服粉防己(千金藤), 可能是治療新冠有效藥物
Pharmacological hypothesis: TPC2 antagonist tetrandrine as a potential therapeutic agent for COVID‐19
Paula M. Heister and Robin N. Poston
低智生物
英國學者：從現有證據, 口服粉防己(千金藤), 可能是治療新冠有效藥物
Pharmacological hypothesis: TPC2 antagonist tetrandrine as a potential therapeutic agent for COVID‐19
Paula M. Heister and Robin N. Poston
其实从实用性来讲，IC50作用浓度有多低并没有太大意义，作用稍弱但安全、成本低的成分，多吃点就行了。
成药性、安全性和成本都很重要，仅仅一个化合物对病毒有强抑制作用并不稀奇，很多用作positive control的化合物作用都很强。
目前我所了解的最好产品应该是UPcare Group的复合型药方，多功能，机制合理，并且安全可靠，价格合适！
成药性、安全性和成本都很重要，仅仅一个化合物对病毒有强抑制作用并不稀奇，很多用作positive control的化合物作用都很强。
目前我所了解的最好产品应该是UPcare Group的复合型药方，多功能，机制合理，并且安全可靠，价格合适！
忽悠，接著忽悠！-----中醫，啥病都敢說“能治”。一根針，一把草藥，就敢吹牛逼啥都能治----馬保國，不堪一擊！
基层理论就不合理。中医里病毒属寒，所以姜黄类温补类治疗有效，大寒类的药怎么可以呢。
美国学者此前也在《科学》发表论文证实。 美国学者？谁啊
实验室结果，还没中试，离成药还有较大差距。人体实验得几年。
回复65楼:
低智生物
英國學者：從現有證據, 口服粉防己(千金藤), 可能是治療新冠有效藥物
Pharmacological hypothesis: TPC2 antagonist tetrandrine as a potential therapeutic agent for COVID‐19
Paula M. Heister and Robin N. Poston
低智生物
英國學者：從現有證據, 口服粉防己(千金藤), 可能是治療新冠有效藥物
Pharmacological hypothesis: TPC2 antagonist tetrandrine as a potential therapeutic agent for COVID‐19
Paula M. Heister and Robin N. Poston
回复70楼:
低智生物
粉防己, 幾塊錢就買到的中藥!!
英國人也在研究!!
英國學者論文：從現有證據, 口服粉防己(千金藤), 可能是治療新冠有效藥物
Pharmacological hypothesis: TPC2 antagonist tetrandrine as a potential therapeutic agent for COVID‐19
Paula M. Heister and Robin N. Poston
低智生物
粉防己, 幾塊錢就買到的中藥!!
英國人也在研究!!
英國學者論文：從現有證據, 口服粉防己(千金藤), 可能是治療新冠有效藥物
Pharmacological hypothesis: TPC2 antagonist tetrandrine as a potential therapeutic agent for COVID‐19
Paula M. Heister and Robin N. Poston
回复65楼:
低智生物
同一中藥, 英國學者也在研究!!
英國學者論文：從現有證據, 口服粉防己(千金藤), 可能是治療新冠有效藥物
Pharmacological hypothesis: TPC2 antagonist tetrandrine as a potential therapeutic agent for COVID‐19
Paula M. Heister and Robin N. Poston
低智生物
同一中藥, 英國學者也在研究!!
英國學者論文：從現有證據, 口服粉防己(千金藤), 可能是治療新冠有效藥物
Pharmacological hypothesis: TPC2 antagonist tetrandrine as a potential therapeutic agent for COVID‐19
Paula M. Heister and Robin N. Poston
回复36楼:
智障
英國學者論文：從現有證據, 口服粉防己(千金藤), 可能是治療新冠有效藥物
Pharmacological hypothesis: TPC2 antagonist tetrandrine as a potential therapeutic agent for COVID‐19
Paula M. Heister and Robin N. Poston
智障
英國學者論文：從現有證據, 口服粉防己(千金藤), 可能是治療新冠有效藥物
Pharmacological hypothesis: TPC2 antagonist tetrandrine as a potential therapeutic agent for COVID‐19
Paula M. Heister and Robin N. Poston
你这和喝消毒水有何区别...... 敌敌畏也能杀死病毒.问题人也死了
回复51楼:
低智生物
英國學者論文：從現有證據, 口服粉防己(千金藤), 可能是治療新冠有效藥物
Pharmacological hypothesis: TPC2 antagonist tetrandrine as a potential therapeutic agent for COVID‐19
Paula M. Heister and Robin N. Poston
低智生物
英國學者論文：從現有證據, 口服粉防己(千金藤), 可能是治療新冠有效藥物
Pharmacological hypothesis: TPC2 antagonist tetrandrine as a potential therapeutic agent for COVID‐19
Paula M. Heister and Robin N. Poston
回复4楼:
低智生物
英國學者論文：從現有證據, 口服粉防己(千金藤), 可能是治療新冠有效藥物
Pharmacological hypothesis: TPC2 antagonist tetrandrine as a potential therapeutic agent for COVID‐19
Paula M. Heister and Robin N. Poston
低智生物
英國學者論文：從現有證據, 口服粉防己(千金藤), 可能是治療新冠有效藥物
Pharmacological hypothesis: TPC2 antagonist tetrandrine as a potential therapeutic agent for COVID‐19
Paula M. Heister and Robin N. Poston
回复2楼:
低智生物
英國學者論文：從現有證據, 口服粉防己(千金藤), 可能是治療新冠有效藥物
Pharmacological hypothesis: TPC2 antagonist tetrandrine as a potential therapeutic agent for COVID‐19
Paula M. Heister and Robin N. Poston
Additional article information
Associated Data
Data Availability Statement
Abstract
More than ten million patients worldwide have been diagnosed with coronavirus disease 19 (COVID‐19) to date (WHO situation report, 1st July 2020). There is no vaccine to prevent infection with the causative organism, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), nor a cure. In the struggle to devise potentially useful therapeutics in record time, the repurposing of existing compounds is a key route of action. In this hypothesis paper, we argue that the bisbenzylisoquinoline and calcium channel blocker tetrandrine, originally extracted from the plant Stephania tetrandra and utilized in traditional Chinese medicine, may have potential in the treatment of COVID‐19 and should be further investigated. We collate and review evidence for tetrandrine's putative mechanism of action in viral infection, specifically its recently discovered antagonism of the two‐pore channel 2 (TPC2). While tetrandrine's particular history of use provides a very limited pharmacological dataset, there is a suggestion from the available evidence that it could be effective at doses used in clinical practice. We suggest that further research to investigate this possibility should be conducted.
低智生物
英國學者論文：從現有證據, 口服粉防己(千金藤), 可能是治療新冠有效藥物
Pharmacological hypothesis: TPC2 antagonist tetrandrine as a potential therapeutic agent for COVID‐19
Paula M. Heister and Robin N. Poston
Additional article information
Associated Data
Data Availability Statement
Abstract
More than ten million patients worldwide have been diagnosed with coronavirus disease 19 (COVID‐19) to date (WHO situation report, 1st July 2020). There is no vaccine to prevent infection with the causative organism, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), nor a cure. In the struggle to devise potentially useful therapeutics in record time, the repurposing of existing compounds is a key route of action. In this hypothesis paper, we argue that the bisbenzylisoquinoline and calcium channel blocker tetrandrine, originally extracted from the plant Stephania tetrandra and utilized in traditional Chinese medicine, may have potential in the treatment of COVID‐19 and should be further investigated. We collate and review evidence for tetrandrine's putative mechanism of action in viral infection, specifically its recently discovered antagonism of the two‐pore channel 2 (TPC2). While tetrandrine's particular history of use provides a very limited pharmacological dataset, there is a suggestion from the available evidence that it could be effective at doses used in clinical practice. We suggest that further research to investigate this possibility should be conducted.
扯鸡巴，中医连个肺痨病都治不好，皇帝都能死在这上边，还吹鸡巴能治新冠。实验室环境的数据并不能说明实际疗效。就跟酒精能杀灭病毒但是喝下去屁用没有一个道理。
回复45楼:
病毒一直在变异，总有些人总想搞出一个或几个不变的化合物去抑制病毒。都是搞笑。
不会治疗感冒的笨蛋，都是这样的笨。
真正会治疗感冒的，根本就不用抑制什么病毒。病毒比这些搞药的笨蛋都聪明，一搞出什么新药，病毒就变异了。
想和病毒赛跑？别逗了。白费劲
病毒一直在变异，总有些人总想搞出一个或几个不变的化合物去抑制病毒。都是搞笑。
不会治疗感冒的笨蛋，都是这样的笨。
真正会治疗感冒的，根本就不用抑制什么病毒。病毒比这些搞药的笨蛋都聪明，一搞出什么新药，病毒就变异了。
想和病毒赛跑？别逗了。白费劲
无知的狗粮又要疯了。不奇怪。中医不是科学。一般的人没有这种智慧。何况这些无脑狗粮。😂😂
院士骗得，我骗不得？防疫钱无穷无尽，有机会骗为何不骗？
Such the stupid people with bias!
It is not suprised that we can find a chemical like this from Chinese medicine herbs which can be used for COVID-19 therapy.
The realted findings were publishd in a peer-reviewed and esteemed Journal--iScience by a JAPANESE group. Here is the link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997640/pdf/main.pdf
iScience is an interdisciplinary open access journal with continuous publication of research across the life, physical, and earth sciences. It is one of the series journal of Cell. The point here is if effect of this chemical for COVID-19 therapy is ture or not. I believe many scientist from different conturies like me are working for this to be the real medicine.
You guys just keep talking about it with your bias. I hope in the future you don't need to take it.
It is not suprised that we can find a chemical like this from Chinese medicine herbs which can be used for COVID-19 therapy.
The realted findings were publishd in a peer-reviewed and esteemed Journal--iScience by a JAPANESE group. Here is the link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997640/pdf/main.pdf
iScience is an interdisciplinary open access journal with continuous publication of research across the life, physical, and earth sciences. It is one of the series journal of Cell. The point here is if effect of this chemical for COVID-19 therapy is ture or not. I believe many scientist from different conturies like me are working for this to be the real medicine.
You guys just keep talking about it with your bias. I hope in the future you don't need to take it.
“这个数字通俗地讲，可以理解为不用千金藤素药物时如果有15393个病毒，在用10微摩尔/升千金藤素药物的情况下，病毒数将只有1个。也就是说，很少量的千金藤素就能阻止新冠病毒扩增和传播。”
效率比消毒水差多了
效率比消毒水差多了
这种植物，我们这遍地都是，除都除不完，你说他能防冠状病毒？那是我不识遍地是黄金啊
人真健忘啊。记得2020年 双黄连，板蓝根等等都领了一把风骚，如今怎么样了呢？还有某大所把美国的合作实验用药申请了应用专利。。。如今又怎么样了呢? 某大学的诺奖级别的基因编辑共聚物，除了骗到国家重点经费，又怎么样了呢？
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目前，已经有加拿大的一家医药企业与美国FDA接洽开展千金藤素的新冠肺炎治疗的临床试验研究，预计该临床试验将在今年下半年正式启动。
楼下，不是天天这个举报FBI，那个上报CIA，难道在美国FDA没人吗？！问一下就知道了。
楼下，不是天天这个举报FBI，那个上报CIA，难道在美国FDA没人吗？！问一下就知道了。
奥巴马都可以获和平奖，这个肯定是医学奖。
既然药都这么有效，国外都正常生活了，为什么政府突然大规模狂发布严格封闭政策。让人无法理解
关键找出其中的有效成分化学组成是什么，古代的老中医你也就是没有工具，估计有现在的研究工具好多药早都研究出真正起作用的成分
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上有所好，下必甚焉。2023年开始全国大中小学集中开展挑麦子山路竞技赛。
先别激动， 弄出药来了才是硬道理。
烧红烙铁杀死新冠病毒的效率是100%， 怎么制成药是一个问题。
烧红烙铁杀死新冠病毒的效率是100%， 怎么制成药是一个问题。
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先别激动， 弄出药来了才是硬道理。
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